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Last Update : August.6.2012
July 2012 Through collaboration between Mahidol University and CellFree Sciences Co., Ltd., Cell-Free Protein Synthesis Workshop was held at the Faculty of Tropical Medicine, Mahidol University, Thailand, from July 25 through July 28.During the workshop, introductory lectures on the wheat germ cell-free system and its applications given, and more than 20 participants had hands-on experience in the wheat germ cell-free protein production. Please visit the following URL for pictures of the workshop. [http://www.tm.mahidol.ac.th/research/client/News.html] |
Feb 2012 CFS launched Premium PLUS Expression Kit, a new two-in-one starter kit, which allows you to use one and the same kit with either plasmid DNA or PCR DNA templates. Based on the high performance wheat germ extract WEPRO®7240, the new kit enables a more than twofold increase in protein yield. |
Jan 2012 During the PepTalk 2012, San Diego, CFS is presenting a poster in the Pipeline4, Choosing, Designing and Optimizing Hosts and Platforms Session, Jan 11-12, 2012. The title of the poster is “Wheat Germ Cell-free Protein Expression System: Yield improvement and expression of membrane proteins.” |
June 2011 The 35th Steenbock Symposium ’Advances in Biomolecular NMR’ will be held June 26-28, 2011, at the University of Wisconsin, Madison. During the symposium, CellFree Sciences will be presenting its technology and products at the exhibition booth. The program of the symposium is available at[http://www.biochem.wisc.edu/seminars/steenbock/symposium35]. |
May 2011 During the 2011 PEGS Meeting, Boston, CFS is presenting a poster in the Difficult to Express Proteins Session, May 9-10, 2011. The title of the poster is “Soluble Expression of Membrane Proteins in Wheat Germ Cell-Free Protein Expression System.” |
March 2011 Please be advised that the recent earthquake and tsunami have not inflicted any damage on our offices, facilities, and families both in Matsuyama and in Yokohama, and that there has been no disruption in shipments of our products. The subsequent trouble at the nuclear power plant in Fukushima is unnerving, but Yokohama being 250 km south of Fukushima and Matsuyama farther to the southwest, we know the best we can do is staying well-informed and level-headed. Many of you have asked us about our health and safety, and we are grateful for your concern. |
July 2010 CFS was cited recently in the following articles:1. Making membrane proteins for structures: a trillion tiny tweaks, 2. FLEXIQuant: A Novel Tool for the Absolute Quantification of |
Nov 2008 On November 24, 2008, the National Institute of Advanced Industrial Science and Technology (AIST) announced the production of its “human protein factory” infrastructure for in vitro proteome research. The infrastructure includes a comprehensive collection of human Gateway entry clones of nearly 15,000 human genes, approximately 70% of the human genome, and their wheat germ cell-free protein expression data. Synthesized in the wheat germ cell-free expression system, nearly all of those clones yielded proteins with soluble fractions. The research that led to the construction of the infrastructure was reported by Goshima and colleagues [1] in Nature Methods, December 2008, which was reviewed by Hartley and colleagues [2] in the same issue. Information and expression data of the Gateway entry clones including SDS-PAGE patterns are available in the URL of Human Gene and Protein Database (HGPD) at http://hgpd.lifesciencedb.jp/ and information of the purchase of those clones is obtained by clicking Clone Inquiry in that URL. [1] N. Goshima et al., Human protein factory for converting the transcriptome into an in vitro-expressed proteome, Nature Methods, 5, 1011-1017 (2008) [2] J. L. Hartley et al., Proteome expression moves in vitro: resources and tools for harnessing the human proteome, Nature Methods, 5, 1001-1002 (2008) |
July 2008 Malaria Vaccine Development - Malaria Protein Synthesis“Research at Ehime University among 23 innovative technologies selected and supported by Japanese Government,” Ehime Shimbun, May 21, 2008 The Council for Science and Technology Policy chaired by Yasuo Fukuda, Prime minister of Japan, drafted a strategy for developing innovative technologies and selected 23 research projects as the global cutting-edge technologies. They will be funded from the next fiscal year onward by a new public fund established by the Council for accelerating the development of those innovative technologies. Among the recipients of new funding is the Malaria Vaccine Development Project at Ehime University using the Cell-Free Protein Expression System developed by Dr. Yaeta Endo of Ehime University. The above strategy is aimed at enhancing the international competitiveness of industries, constructing healthy society, and strengthening the security of Japan and the rest of the world by supporting innovative technologies expected to have ripple effects on society. The selected technologies, one of which is regenerative therapy using iPS cells, encompass broad areas including information and communication technology, healthcare, and agriculture. Of the fiscal 2008 outlay of 1.4 trillion yen for science and technology promotion, 1% will be allocated to the innovative technology strategy. In search of malaria vaccine candidates, Ehime University has started a joint research project with international collaborators including an Australian institute. In the heart of this search is the cell-free protein expression system, whose advent has made it possible to efficiently synthesize malaria parasite proteins beyond the limit of the commonly used E. coli system. The Council for Science and Technology Policy states that the plant-based protein synthesis technology used in the Malaria Vaccine Development Project at Ehime University permits efficient production of a variety of malaria-related proteins for malaria vaccine development. By this statement, the Council expresses high expectation for the production of malaria vaccines in near future. |
July 2008 ExhibitionEvents: XXI Congress and General Assembly of the International Union of Crystallography yIUCr2008 Osaka, Japan(http://www.iucr.org/iucr-top/index.html)z Time and Dates: 9:00 - 17:00, August 24 - 27, 2008 Venue: Osaka International Convention Center (3F, Event Hall), Osaka, Japan Exhibits: Wheat germ cell-free expression system, reagents, and kits. Introduction of a compact protein synthesizer for large-scale production for structural analysis |
March 2007 Novel Analytical Method for Searching for Inhibitors of Cancer-Related ProteinsJoining forces with Taiho Pharmaceutical Co., Ltd., CellFree Sciences Co., Ltd. developed a novel analytical method for searching for inhibitors of cancer-related proteins. This followed Taiho's discovery of proteins including target proteins that play roles in cancer cell growth. We synthesized those proteins in our wheat germ cell-free expression system to develop a technique for high-throughput screening of compounds. The new method permits (1) high-throughput search for inhibitors and (2) speedy identification of a specific protein that may be affected by an inhibitor and the specificity thereof. Its successful development is attributable to high-speed expression of active proteins using a desktop robot, Protemist DT, coupled with our newly developed high-speed protein modification and high-sensitivity assay technology. Multiple units of Protemist DT have been in operation, besides Taiho, at Kyoto University, University of Tokyo, and other major research centers in Japan. Our services include development of tools for the functional analysis of proteins and protein-protein interaction. Two units of Protemist DT II, a new version of DT, have been added to the CESG of the University of Wisconsin, Madison. |