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NEWS
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Last UpdateFJuly 04,'07 |
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March 2007
Novel Analytical Method for Searching for Inhibitors of
Cancer-Related Proteins
Joining forces with Taiho Pharmaceutical Co., Ltd., CellFree Sciences Co., Ltd. developed a novel analytical method for searching for inhibitors of cancer-related proteins. This followed Taiho's discovery of proteins including target proteins that play roles in cancer cell growth. We synthesized those proteins in our wheat germ cell-free expression system to develop a technique for high-throughput screening of compounds.
The new method permits (1) high-throughput search for inhibitors and (2) speedy identification of a specific protein that may be affected by an inhibitor and the specificity thereof. Its successful development is attributable to high-speed expression of active proteins using a desktop robot, Protemist DT, coupled with our newly developed high-speed protein modification and high-sensitivity assay technology.
Multiple units of Protemist DT have been in operation, besides Taiho, at Kyoto University, University of Tokyo, and other major research centers in Japan. Our services include development of tools for the functional analysis of proteins and protein-protein interaction. Two units of Protemist DT II, a new version of DT, have been added to the CESG of the University of Wisconsin, Madison.
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October 2006
Cell free workshop at RIKEN Yokohama successfully completed.
As a satellite conference of ICSG 2006, hands-on workshop at RIKEN Yokohama was held for 4 different courses from October 18th to 21st. The four workshops were completed with great success. Cell Free Sciences Co.Ltd joined the course 1,[Cell free protein expression course] as a co-sponsor providing premium expression kits to all the participants of course 1 to conduct protein expression experiment with wheat germ technologies. CFS also exhibited brand new auto-synthesizer called Protemist DT-II. There were28 scientists joined the course 1 from all over the world. We also introduced prototype synthesizer for large scale protein production in the course which caught high level of interest from the participants.
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October 2006
We have entered into a strategic partnership today with Emerald BioSystems, Inc. (Emerald) to enhance each companyfs development, marketing, and sales activities in North America, Europe, and Japan. By working together, CFS and Emerald will make use of significant synergies in their respective product lines ranging from synthetic gene design software (Emeraldfs Gene Composer™) to sophisticated laboratory automation and reagents for cell-free protein production (CFSfs ENDEXTR® reagents and Protemist® instruments) and to protein crystallization. |
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October 2006
Under the clear autumn sky, the 4th Protein Island Matsuyama (PIM) International Symposium 2006 was held at ANA Hotel Matsuyama on October 6, 2006. More than 200 researchers, engineers, and students listened to the presentations focused on potential applications of the cell-free protein synthesis technology. On Sunday, October 8, a seminar for the general public titled gFrom Ehime to the World - Challenges in Biosciencesh was held at the Matsuyama City Welfare Center. More than 350 people enjoyed the occasion. Please go to the following URL for more detail of the symposium:
http://www.pim-sympo.jp/2006/english/index.html |
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September 2006
R elated article on Wheat Germ Cell Free Protein Expression Workshop held at University of Wisconsin,Madison,WI.USA.
related article |
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September 2006
A unit of Protemist DT, CFSfs desktop protein synthesizer, has been installed at the laboratory of Professor Masayuki Murata of the University of Tokyo, Graduate School of Arts and Sciences. Being capable of producing and purifying proteins of interest overnight, the unit is to supply proteins to the screening system built by Professor Murata.
Designed for the functional analysis of proteins, Professor Muratafs screening system uses semi-intact cells in combination with visualization by an optical microscope. For this system, Protemist DT was selected as the best available protein synthesizer, with high credit given to its purification capability integrated into the fully automatic protein synthesis.
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September 2006
A unique workshop for hands-on experience in wheat germ and other cell-free protein production systems will be held from 3 p.m. on October 18th to noon on October 21st at Yokohama City University and RIKEN Yokohama Institute. It is organized by Professor Yaeta Endo ( Ehime University ) and Project Director Shigeyuki Yokoyama ( RIKEN ) as one of the satellite workshops of the International Conference on Structural Genomics (ICSG) 2006.
CellFree Sciences, Co., Ltd. supports this workshop.
For more detail, please go to http://stone.gsc.riken.jp/icsg2006/index.html
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August 2006
Wheat Germ Cell-Free Protein Production Workshop in University of Wisconsin ended successfully.
Please see the following URL for hot news of the workshop.
http://www.uwstructuralgenomics.org/cellfree_workshop.htm
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July2006
University of Wisconsin-Madison to hold Wheat Germ Cell-Free Protein Production Workshop
The Center for Eukaryotic Structural Genomics (CESG) and the Nuclear Magnetic Resonance Facility (NMRFAM) at the University of Wisconsin-Madison are holding the 2006 Wheat Germ Cell-Free Protein Production Workshop from July 30 through August 5, 2006. This unique workshop gives the participants hands-on experience in the wheat germ cell-free production of their own target proteins on a microgram and milligram scale. Seminars on related subjects are also held. Participants, representing major structural biology centers, academic institutes, and private companies, will come from US, Europe and Asia. The CellFree Sciences Co, Ltd. Japan, Promega Corporation, USA and Cambridge Isotope Laboratories, USA co-sponsor the workshop. The CESG at University of Wisconsin-Madison is one of the leading structural biology centers supported by the National Institute of General Medical Sciences (NIGMS) Protein Structure Initiative, ultimately aiming at making the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences.
Prof. John Markley and Dr. Dmitriy Vinarov at the CESG in collaboration with Professor Yaeta Endo, Ehime University, and the CellFree Sciences, Co., Ltd have developed high throughput Wheat Germ Cell-Free Protein Production Platform for NMR, to breakthrough the bottleneck of high throughput labeled protein production. CESG has successfully determined 3-D structure of not less than 90 proteins, which have subsequently been registered at Protein Data Bank.
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March 2006
We have renewed our Web Site.
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January 2006
Pacific Northwest National Laboratory (PNNL), one of the nine national laboratories of the U.S. Department of Energy, employed the CFS automatic protein synthesizer GenDecoder1000. PNNL will use it to synthesize proteins required for Genomes to Life (GTL) program, whose focus is on the molecular machines of DOE-relevant microbes and their networking in living cells and microbial communities. GenDecoder1000 is capable of transcription and translation of 384 samples in an overnight campaign. |
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