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Our research and development activities were introduced in the weekly Ehime Economic Report.

Category: Press releases Created: Thursday, 11 November 2021

The weekly Ehime Economic Report (November 8, 2021) No. 2273 introduced our efforts to develop "Targeted Proteolytic Drug (TPD)" in cooperation with Ehime University.

The movies introducing wheat cell-free protein synthesis technology and its applications is now available on the Protein Island Matsuyama (PIM) website.

Category: Press releases Created: Sunday, 01 August 2021

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The movies introducing the wheat cell-free protein synthesis technology and its applications was created and released as one of the programs of Protein Island Matsuyama (PIM) 2020,












CellFree Sciences Co., Ltd. received support from Ehime Prefecture under the "Ehime Prefecture New Growth Manufacturing Company Comprehensive Support Program in FY2021".

Category: Press releases Created: Friday, 30 July 2021


We are grateful, that Ehime Prefecture selected an application by CellFree Sciences under their "Ehime Prefecture New Growth Manufacturing Company Comprehensive Support Program in FY2021".



Having access to a unique set of about 23,000 human full-length proteins, CellFree Sciences will apply their own technologies including a protein bead array platform to search for new drug targets and therapeutic concepts.


While about 10 to 15% of the human proteins could play a role in disease, presently only about 2% of the human proteins can be directly targeted by a drug. Hence, there is a clear need to expand the number of druggable proteins to develop new therapeutic concepts and to cover a wider range of disease. In this project, we will apply new concepts to target drug targets for proteolytic degradation utilizing E3 ligases. Having extensive knowledge on E3 ligases, it is hoped that utilizing E3 ligases will offer new leads allowing for targeted proteolysis of selected targets while having less side effects than other drug candidates.


Project period: July 5, 2021-February 28, 2022.









Dr. Yaeta Endo, Special University Professor Emeritus, received the Ehime News Paper's Award

Category: Press releases Created: Monday, 17 May 2021

Dr. Yaeta Endo, who is the Special University Professor Emeritus, received the Ehime News Paper’s Award for developing wheat germ cell free protein expression system.


愛媛新聞賞・スポーツ賞贈呈式 松山|愛媛新聞ONLINE (


The development serological markers for detecting recent Plasmodium vivax infection has been successful

Category: Press releases Created: Tuesday, 12 May 2020

The international research group comprising of Proteo-Science Center, Ehime University’s Dr. Eizo Takashima, Dr. Masayuki Morita, and Dr. Takafumi Tsuboi along with CellFree Sciences Co., Ltd.’s Dr. Matthias Harbers succeeded in developing a serological diagnostic marker that can identify those with dormant liver stage infections, which are the causes of Plasmodium v​​ivax recurrences.


This result has been achieved by an international joint research project with the main members including Proteo-Science Center, Ehime University, CellFree Sciences Co., Ltd., The Walter and Eliza Hall Institute of Medical Research (WEHI), Pasteur Institute, and Foundation for Innovative New Diagnostics (FIND).

Further, this project was started with assistance from the Global Health Innovative Technology Fund (GHIT Fund) between October 2015 and March 2017.


This research result allows the diagnosis of Plasmodium v​​ivax’s dormant liver stage parasites which has been a difficult challenge in eliminating malaria, for the first time in the world. It can be seen as an important result to safely and effectively promote the treatment.


The paper regarding this research result has been published on the May 12th (Tues.) 2020 issue of the Nature Medicine.

Development and validation of serological markers for detecting recent Plasmodium vivax infection


Additional comment


We in collaboration with Ehime University have developed a new technology to conduct a genome wide evaluation of the specificity of antibodies that can bind to human proteins.

Category: Press releases Created: Thursday, 19 December 2019

The groups from CellFree Sciences Co., Ltd. (Ryo Morishita, R&D manager)  and  Proteo-Science Center, Ehime University (Professor Tatsuya Sawasaki) have successfully developed a new technology that identifies proteins for binding to target antibodies. Using about 20,000 human proteins this technology is best suited for veriflying the specificity of antibodies against human proteins.


The new technology utilizes a protein bead array technology developed by CellFree Sciences Co., Ltd. named “CF-PA2Vtech”. The potential of the new method was demonstrated by verifying the specific binding of a commercial anti-PD-1 antibody, where the data demonstrate its binding to several proteins having related linear epitopes.


The results from the research were published by Morishita et al. in the December 18, 2019 issue of Scientific Reports:


CF-PA2Vtech: a cell-free human protein array technology for antibody validation against human proteins

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