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A set of 1118 human transcription factors was made by our expression system to study side effects of "thalidmide" | CellFree Sciences

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A set of 1118 human transcription factors was made by our expression system to study side effects of "thalidmide"

Category: Announcements Created: Friday, 22 January 2021

A joint effort by several universities and research institutes in Japan, including our strategic technology partners Dr. Satoshi Yamanaka and Professor Tatsuya Sawasaki at the Proteoscience Center of Ehime University, conducted a comprehensive study using a human protein array comprising 1,118 human transcription factors produced in our wheat germ cell-free protein expression system. Screening those proteins led to the discovery that thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF.

 

Thalidmide was originally used as a sleeping drug for pregnant women but had caused terrible side effects. Later it was found that Thalidmide and its derivatives are potent drugs for treating leprosy and multiple myeloma. These are highly effective drugs that are now sold for about 1 trillion yen per year in the world for treatment of blood cancers such as multiple myeloma. However, these drugs require a strict safety management to avoid teratomas. The new finding reported here will help to develop better thalidmide derivatives that could avoid any risk for teratoma formation.

 

For details, please click here.

 

Please click here for a paper on this research.

 

 

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